I've always used PVA. The thing is with it, when it has set it is still very slightly flexible. So it will absorb
a certain amount of stress before it breaks. The secret of a good join is the combination of a glue and a
mechanical fixing. A nail on it's own will hold the joint, but will move if stressed. Glue on it's own will hold
but if it breaks the whole issue falls apart. Glue and nails work in concert. The nails mitigate any stress on
the glue bond and the glue stops any movement.
Some glues are brittle. The fast-setting two-part Epoxy is strong but very brittle when cured. The slower (2hr)
setting stuff is much tougher. Both need to be clamped while curing or the joint can actually be forced apart.
Same applies to Polyurethane glue. Very strong but very user-unfriendly.
A glue joint needs pressure to get a good bond. Pressure will force the glue into the wood somewhat and
ensure that the maximum area is fixed firmly.
I have on occasion had to break frames apart, so the opportunity to test joins arises. I did one once that had
an very chunky moulding. It was basically a bit of 4x2 with a few bits milled off. I got it on sp offer, otherwise
I would have avoided it.

. I used two biscuit slots, glued the whole thing up and cinched it up with a webbing
strap. While clamped I put two 4" woodscrews across each corner. Way too big to underpin. It joined well after
a bit of persuasion, but unfortunately one rail must have been warped so a corner was a misaligned. Tried a bit
on judicious sanding to try and disguise it but couldn't quite manage it. So I tried to break it down. Even with my
huge strength I couldn't break it.

Had to take saw to it.
The moral is: Large glue area + pressure on the join + solid mechanical fittings = Strong Join.
