If it is a truly sealed system, the desiccant will not become saturated. In semi sealed situations the gel needs to be changed periodically. There are formulas for how much to use/volume of air;some are made to change color when they are saturated. If packaging permits, silica gels can be "recharged" by heating them to drive out stored moisture. They can also act as a moisture sinks - absorbing and releasing moisture according to ambient conditions.
Zeolites can be engineered to absorb and "lock" moisture and gaseous pollutants. Artcare is engineered to absorb pollutants, not moisture. It will not release them. When it is exhausted, it needs to be changed. It does not change color when it is exhausted, but is supposed to last many years in normal framing conditions. there are also zeolites that are designed to absorb and lock moisture.
I have treated pieces that became mold damaged after 6 months in Jakarta, in unsealed frames.
Rebecca