The article posted by Jon has some interesting points that not all framers (and artists) are likely aware of.
I know I wasn't.
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Summary
Stretcher keys (and expansion bolt mechanisms) are
appropriate for use by the artist prior to completion of the painting. However,
their use long after the creation of the work of art has the potential to cause more serious problems than they set out to solve. The structural appearance of a stretched canvas painting is dictated by the mechanical properties of the component parts (fabric, wood of the stretcher, glue size, ground and paint layers), all of which are affected by ambient RH and temperature. The stiffest layer (or layers) will generally dictate the overall behaviour of the painting. This layer is rarely, if ever, the canvas, especially as the painting ages; it is almost always the glue size.
Tautness in the painting as it is exposed to low RH levels will gradually diminish as the stretcher shrinks slightly and brittle layers undergo stress relaxation over time. As the humidity begins to increase, the stretcher swells and expands and the canvas is pulled slightly tighter. Differences in compression between the centre of the canvas and the outer edges should diminish along with corner draws. However, as a painting ages, the canvas weakens and paint and ground layers lose their resiliency, which makes them susceptible to cracking. Slackness does not always resolve itself.
Keying out a painting may appear to be the solution for correcting slackness or local deformations; however, cracking or worsening of cracks, loss of paint and tears along tacking edges will be the result.
If the painting cannot resolve its structural integrity through exposure to mid-range RH levels (40% to 60% RH), then advice and intervention by a professional conservator should be sought. Optimally, display or store paintings where ambient humidity is between 40% to 60% RH and temperature is between 18°C and 24°C. For added protection, or where conditions are not optimal, a backing board and glazing in the frame can buffer the painting from short-term fluctuations in the ambient environment.
Although keying out of paintings is not recommended, loose keys must be secured in order to stabilize stretcher corners and to prevent keys from falling between the stretcher bars and the canvas. Only finger pressure should be used to press in keys, and these should be further secured by methods referred to in CCI Note 10/8
Framing a Painting.
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I hadn't read the cautions in this article regarding keying stretchers anywhere else.
Food for thought.
I do canvas on strainers, only because that was how I was shown.
I've considered switching to stretchers, but now I'm not so sure.