Howdy
It does work fine on Vista.
Which A/V program are you using? I'm aware of a small issue that some folks with Kaspersky are experiencing, and a fix is in the works. (Kaspersky blocks the installer for SOME people, but not others)
Try this:
1) If running Kaspersky, disable it briefly (Right click red K down on system tray and QUIT).
2) Click START -> COMPUTER -> C: (Local Disk) -> LIFESAVER (yellow folder) -> PROGRAM_UPDATE (yellow folder)
3) Double click the 5111UPDATE file to manually reinstall.
4) Reboot the computer when prompted, after the install has completed. This will also re-enable the a/v program.
Hopefully that'll fix up any issue that you have.
Mike
PS: If you don't use Kaspersky antivirus, it's ok to try steps 2-4 anyways.