Ken,
Welcome to the Grumble and congratulations on taking this important step to modernize and organize your operation!
There was a recent thread in the computer & POS forum that posed the same question, and had a lot of positive feedback. Rather than duplicate the response, i'll link you to the other post. Inside the post, you'll find some great advice as well as links to a POS Comparison List, the recent grumble survey about pos software, and an article from PFM (Feb 2006) that went over the benefits of going with a POS and some tips for selecting one to fit your needs.
It requires a bit of research, to try the various demos and see what you and your staff are comfortable with. Note that everyone will be proud of their choice, and may not be familiar with what else is out there. Because of that, I suggest grabbing the demos to form your own opinion. The top systems share similar features and benefits, and all have great tech support.
If you will be using the product with the new Windows Vista, check with the vendors to make sure it is supported. I know that Vista does NOT yet work with any of the visualization systems. I have tested Vista here with LifeSaver, and it works.
If you scan through the Tech & Software forum, you'll find a lot of opinions and advice.
http://www.thegrumble.com/showthread.php?t=23198
Best regards and welcome to the Grumble!
Mike Labbe
co-moderator
one of the resident computer geeks